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Giriş Bölüm Personel Lisans Lisans Üstü Hizmetler Duyurular MOBGAM İletişim

 

Yrd. Doç. Dr.

ASLI KUMBASAR

İstanbul Teknik Üniversitesi

 Fen-Edebiyat Fakültesi

 Moleküler Biyoloji ve Genetik Bölümü

 

34469 Maslak-İstanbul

 

Tel: 212-285 7258

 Fax: 212-285 7254

e-posta: kumbasara@itu.edu.tr

 

 

<< Geri


 

Akademik dereceler ve çalışma deneyimi


Yrd Doç. Dr. - İstanbul Teknik Üniversitesi, Fen-Edebiyat Fakültesi, Moleküler Biyoloji ve Genetik Bölümü , İstanbul, 2010- halen.

Doktora Sonrası Araştırmacı - University of Maryland, Baltimore, Department of Anatomy and Neurobiology, Baltimore, MD, USA, 2006-2010.

Uzman Araştırmacı - TÜBİTAK, Gen Mühendisliği ve Biyoteknoloji Araştırma Merkezi, Gebze- Kocaeli, 2001-2006.

Doktora - Massachussetts Institute of Technology, Cambridge, MA, USA, Biyoloji, 2000.

Yüksek Lisans – Brandeis University, Waltham, MA, USA, Biyokimya 1990.

Lisans - Brandeis University, Waltham, MA, USA, Biyokimya 1990.
 


 

İlgi alanları

 

Sinir kök hücrelerinde nörogenez ve gen ekspresyonu regülasyonu

NFI transkripsiyon faktörlerinin çalı
şma mekanizmaları
 


 

Yayınlar

 

Uluslararası hakemli dergilerde yayımlanan makaleler :

1. Kumbasar A., C. Plachez, R. M. Gronostajski, L.J. Richards and E. D. Litwack (2009). Absence of the transcription factor
Nfib delays the formation of the basilar pontine and other mossy fiber nuclei. J. Comp. Neurol. 513:98-112.

2. Erdag B., B.K. Balcioglu, A. Kumbasar, O. Celikbicak, G. Zeder-Lutz, D. Altschuh, B. Salih. and K. Baysal (2007). Novel
short peptides isolated from phage display library inhibit vascular endothelial growth factor activity. Mol. Biotechnol. 35:51-64.

3. Korkmaz M., B.H. Guvenc, A. Bilir, O. Karal-Yilmaz, A. Kumbasar, J. Caferler and K. Baysal (2003). Isolation and culture of
adult and fetal rabbit bladder smooth muscle cells and their interaction with biopolymers. J. Pediatr. Surg., 38:21-4.

4. Erdag B., B.K. Balcioglu, A. Kumbasar and B. Cirakoglu (2003). Detection of phage displayed peptides with blocking ability
in vascular endothelial growth factor (VEGF) model. Adv. Exp. Med. Biol., 534:327-34.

5. Kleeff J., S. Wildi, A. Kumbasar, H. Friess, A. D. Lander and M. Korc (1999). Stable transfection of a glypican-1 antisense
construct decreases tumorigenicity in PANC-1 pancreatic carcinoma cells. Pancreas, 19: 281-8.

6. Kleeff J., T. Ishiwata, A. Kumbasar, H. Friess, M. W. Buchler, A. D. Lander and M. Korc. (1998). The cell-surface heparan
sulfate proteoglycan glypican-1 regulates growth factor action in pancreatic carcinoma cells and is overexpressed in human
pancreatic cancer. J. Clin. Invest., 102: 1662-73.

7. Litwack E. D., J. K. Ivins, A. Kumbasar, S. Paine-Saunders, C. S. Stipp and A. D. Lander (1998). Expression of the heparan
sulfate proteoglycan glypican-1 in the developing rodent. Developmental Dynamics, 211: 72-87.

8. Ivins J. K., E. D. Litwack, A. Kumbasar, C. S. Stipp and A. D. Lander (1997). Cerebroglycan, a developmentally regulated
cell-surface heparan sulfate proteoglycan, is expressed on developing axons and growth cones. Developmental Biology, 184: 320-32.

9. Litwack E. D., C. S. Stipp, A. Kumbasar and A. D. Lander (1994). Neuronal expression of glypican, a cell-surface
glycosylphosphatidylinositol-anchored heparan sulfate proteoglycan, in the adult rat nervous system. J. Neurosci., 14: 3713-24.

Uluslararası bilimsel toplantılarda sunulan ve bildiri kitabında (Proceedings) basılan bildiriler :

1. Kumbasar A., and E. D. Litwack (2009). Identification of genes regulated by Nfib, a transcription factor that controls pontine
neurogenesis in the developing mouse hindbrain. Society for Neuroscience Abstracts 606.6.

2. Kumbasar A., R. M. Gronostajski and E. D. Litwack (2008). Regulation of pontine development by the transcription factor Nfib.
Society for Developmental Biology Annual Meeting. L31.

3. Kumbasar A., R. M. Gronostajski and E. D. Litwack (2007). Molecular mechanisms underlying the regulation of basilar pontine
development by the transcription factor Nfib. Society for Neuroscience Abstracts 31.2.

4. Basalp, A., F. Yucel, A. Kumbasar and K. Baysal, K (2006). Development and characterization of monoclonal antibodies to VEGFR2.
FEBS Journal, 273:273 PP724.

5. Erdag, B., K. Balcioglu, A. Ozdemir, A. Kumbasar and K. Baysal (2006). Production and characterization of neutralizing single-
chain antibodies against human VEGFR-2. FEBS Journal, 273:274-5 PP731.

6. Yucel, F., S. Ozturk, A. Kumbasar, M. Serhatli, B. Erdag, K. Balcioglu, A. Basalp, and K. Baysal, K (2006). Production of
monoclonal antibodies against vascular endothelial growth factor. FEBS Journal, 273: 275 PP732.

7. Sanchez-Duran J.A., E. Kanakubo, L. Pham, A. Kumbasar, M. Stigson and A. D. Lander (2003). Evidence for a GPI-anchored coreceptor
in bone morphogenetic protein signaling. Developmental Biology 259:462.

8. Lander A.D., K. Ding K, E. Kanakubo, A. Kumbasar, Q. Nie, L. Pham, J. A. Sanchez and F.Y.M Wan (2002). Interplay of receptors,
coreceptors, and molecular diffusion in the regulation of developmental signaling. Developmental Biology 247:478.

9. Basalp A., F. Yucel, A. Kumbasar and K. Baysal (2002). Function blocking antibodies against Human Vascular Endothelial Growth
Factor: Production and Characterization. European Journal of Biochemistry 269: PS5-021.

10. Erdag B., K. Balcioglu, A. Kumbasar and B. Cirakoglu (2002). Selection of phage displayed peptides that block binding of
Vascular Endothelial Growth Factor (VEGF) to VEGF Receptor. European Journal of Biochemistry 269: PS1-033.

11. Korkmaz M., G.H. Güvenc, A. Bilir, O.K. Yilmaz, A.Kumbasar, J. Caferler and K. Baysal (2002). Isolation and culture of adult and
fetal rabbit bladders smooth muscle cells and their interaction with biopolymers. British Association of Paediatric Surgeons, XLIX
Annual Congress, Abstract 11.

12. Kumbasar A. and A. D. Lander (1999). A GPI-anchored co-receptor. Molecular Biology of the Cell, 10: 183a.

13. Lander A.D., R.L. Chen, D.E. Emerling, J.K. Ivins, A. Kumbasar, S.E. Paine-Saunders and S. Saunders (1997). Roles of
proteoglycans in nervous system development. Glycobiology, 7:20.

14. Kumbasar A., E. D. Litwack, C. S. Stipp, J. K. Ivins and A. D. Lander (1994). Localization and functional analysis of
Cerebroglycan in the developing nervous system. Molecular Biology of the Cell, 5: 303a.

15. Litwack E. D., A. Kumbasar, J. K. Ivins and A. D. Lander (1994). Expression of the heparan sulfate proteoglycan in the
developing rat nervous system. Molecular Biology of the Cell, 5: 301a.

16. Lander A. D., A. Kumbasar, E. D. Litwack and C. S. Stipp (1993). The glypican family of Glycosylphosphatidylinositol-anchored
heparan sulfate proteoglycans in the developing rat brain. Society for Neuroscience Abstracts, 19: 1480.

Ulusal bilimsel toplantılarda sunulan ve bildiri kitaplarında basılan bildiriler:

1. Öztürk, S., A. Kumbasar, B. Erdag, B. K. Balcioglu, K. Baysal ve B. Cirakoglu (2003). Antianjiyogenik tedaviye yönelik
olarak anti-vasküler endotel büyüme faktörü antikorlarinin olusturulmasi ve karakterizasyonu. XV. Ulusal Kanser Kongresi, 23-27
Nisan 2003, P132.

 


 

Projeler:

 

Transciptional Regulation of Pontine Development, NIH , Araştırmacı, 2006-2010.

Antianjiyogenik Antikanser Uygulamaların In Vitro Olarak ve Hepatosellüler Kanser Oluşturulmuş Transgenik Farelerde in Vivo Olarak
Gerçekleştirilmesi” TÜBİTAK, SBAG, Araştırmacı, 2001-2006.
 


 

Bilimsel ve Mesleki Kuruluşlara Üyelikler


Society for Neuroscience
American Association of Anatomists
Turkish American Scientists and Scholars Association

 


 

Verilen dersler


BIO211E Cell Biology
MBG521 Advanced Cell Biology

 

 

İstanbul Teknik Üniversitesi, Moleküler Biyoloji ve Genetik Bölümü

Maslak 34469 İstanbul, Türkiye
Tel: 0212 285 3255 (Böl. Bşk.); 212 285 3301, 3313 | Faks: 0212 285 6386

Son güncelleme:

05.Eki.2008

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